When such scientific information is incorrect, highly questionable, or misapplied even within the field of science, then it becomes problematic, i.e., scientific "misinformation" instead, expanding inaccuracies, becoming imbedded within the theoretical structures of those other fields, and possibly misguiding public policy officials who rely on scientific experts.

                The aim of this paper** is to suggest to the scientific community the theoretical and practical consequences of such scientific misinformation on the fields of philosophy, theology, biomedical ethics and public policy.

                The method will be to take only one major current issue which has its source in scientific data and argumentation, and trace the impact of that scientific "misinformation" on those other fields.  To narrow the issue I will trace scientific misinformation concerning human embryogenesis - specfically, exactly when, during human embryogenesis, is there present a human being or a human person?

                I want to emphasize that this paper is not about describing methods of data auditing (although it would support the need for such important procedures).  Nor is it about proving or disproving when fetal "personhood" takes place.  That issue has already been discussed at great length in the references provided.  Rather, regardless of one's own position on fetal personhood, the aim of this paper is to identify the science actually used in these arguments, consider the apparent contradiction of this science with that stated by other scientists, and trace the impact of the science actually used on the theories of other fields.

                  In addition, since the philosophy and the science used in the arguments of fetal "personhood" are often complexly intertwined, I will resort at times to clarifying at least some general philosophical concepts in order to make the scientific problems inherent in these arguments coherent.  Because most of the arguments are in fact drawn from writers who cross interdiscplinary lines, the categories of "philosophy", "theology", "biomedical ethics" and "public policy" can only be roughly drawn.  The point is to see how scientific data and arguments stated by scientists find their way into current arguments in those others fields.

IMPACT ON OTHER FIELDS:

I.  Philosophy/Theology/Biomedical Ethics:  "Early" Embryonic and Fetal Development

The field of philosophy is difficult to define.  Unlike science or mathematics, there is no general agreement on what its subject matter is, or on its methodology.  It is agreed - at least by those philosophers who have studied the whole history of philosophy - that there are many different schools of philosophy, each characterized by certain different basic presuppositions and explanations of the world.  The philosophy of science is no exception.  As in all other sub-fields of philosophy, the philosophy of science embraces all of the very different and often contradictory schools of thought, e.g., monism, dualism, rationalism, empiricism, scholasticism and realism.  Even these very terms are defined differently by different schools.  There is, then, no such thing as a "neutral" philosophy, a "neutral" ethics", or even a "neutral" logic.

                For most realistic schools of philosophy, to which this writer subscribes, it is critical to obtain the most accurate scientific data and theories about the physical world as is possible, as these scientific facts and theories are the starting points for all other philosophical endeavors.  There are many important technical philosophical terms whose definitions are derived from and refined by scientific data - even for example, the seemingly vague philosophical term "being".  For present purposes, a "being", generally speaking, is a subsistent substance of a particular kind whose nature determines its kind, and causes certain specific kinds of functions and activities.  There are many different natures or kinds of beings, and thus many different specific kinds of functions and activities.  For example, fish can swim but trees cannot;  frogs produce frog enzymes and proteins, but tomato plants or giraffes cannot.  A being also sustains typical secondary or accidental modifications.  For example, a mushroom is a particular kind of plant-being;  and it can be modified accidentally by being white or black, small or large, edible or poisonous.  Again, a horse is a certain kind of animal-being;  and it can be modified accidentally by being of a solid color or spotted, roan or bay, short or tall.  Mushrooms and horses are examples of substances or beings.  White, black, edible, poisonous, spotted, roan and tall are examples of accidental modifications of those beings.  Changes in accidental modifications do not change the nature or kind of being it already is.  (E.g., an apple can change from green to red, but it is still an apple).  

                Not only do scientific observations of the world lead us to specific definitions of each of the many different natures or kinds of material beings in the world;  they can also lead to analogous definitions of properties which are "common" to all beings whatsoever.  All of these definitions should "match" as closely as possible that scientific data from which they were drawn - otherwise we are not theorizing about the real world at all (Irving, 1992).  Obviously, if there is an error in the scientific observations or data, then our concepts about the real world, which are drawn from and represent to us those scientific observations, are in error as well.  A realist's philosophical concepts and theories, then, must match the best and most accurate scientific data and theories about the real world.

                Another general technical philosophical term whose definition is impacted by scientific data is the term "individual".  Speaking generally an "individual" is that which is essentially unified, and one with, or the same as, itself.  For example, a horse is an individual being;  a herd of horses are many individual beings.  In contrast to the "accidental" modifications above, "individuality" is such a "common" technical term defining an essential and non-accidental attribute of a being.  That is, a being cannot be a being unless it is "one" being.  Needless to say, if the definition of "being" is incorrect, the definitions of "human being" and "material being" are also incorrect - and the definitions of "ethics" and of "science" will be incorrect as well.

                To the point, two other philosophical terms have recently been affected by the scientific evidence presented in the literature, i.e., the terms "human being" and "human person".  Many articles have been written addressing the question of when during human embryogenesis is there present a human being?  And is a human being the same as a human person - or does a human person come later in human embryogenesis than a human being? 

                For purposes of laying out how others have addressed the issue, and to provide several references to which one might turn to obtain a more detailed treatment of the arguments, some writers will use scientific information to argue that a human being is simultaneously a human person - they cannot be separated (Lejeune, 1989;  Irving, 1991, 1992;  Fisher, 1991;  Ashley, 1987; Klubertanz, 1953; Carberry and Kmiec, 1992;  Howsepian, 1992;  Moraczewski, 1983;  Barry, 1979;  Daly, 1987;  Werner, 1974;  Wertheimer, 1971;  Brody, 1978;  Santamaria, 1982;  Grisez, 1970;  Iglesias, 1984;  Quinn,  1984;  Commonwealth of Australia, 1985;  Parliamentary Assembly of the Council of Europe, 1986;  Congregation for the Doctrine of the Faith, 1987).  Their arguments claim that functionally, genetically and biochemically it is clear that a new unique living individual human being, who simultaneously is a human person, is present at some point during fertilization, at least by the point in fertilization called "symgamy" - that moment in time and space during the process of fertilization when there is the last crossing-over of the maternal and paternal chromosomes.  It is at that moment when substantial change has taken place.  That is, when the "23" chromosomes of the human ovum and the "23" chromosomes of the human sperm have combined to form a human zygote with "46" chromosomes (generally the number and combination of the human species) then a change in natures has taken place.  The nature of the sperm and the nature of the ovum have changed to the nature of the embryo - as one can determine scientifically by the differences in biochemical and biological functions and activities of the sperm, egg, and zygote.  Certain realistic philosophical schools of thought, which always use the scientific facts as their starting points in conceptualizing the real world, are often evoked which seem to "match" this biological data.  This data grounds the argument that from the moment of syngamy there already exists an individual human being with the "potency" (or nature) to develop continuously through the later stages of human embryogenesis and adulthood.  Thus embryological development - in contrast to fertilization - is identified as an example of accidental change, i.e., the nature does not change but the accidents do  (Irving, 1991, 1992;  Klubertanz, 1953).

                "Potency" is a realist philosophical term used to designate an already existing nature of a particular kind of thing which already has the present capacity or power to direct the development of itself throughout its accidental developmental stages.  In current discussions this term is constantly corrupted and construed to mean "potential" or "possibility", implying that the nature in question is not there yet, but might be there sometime in the future.  For purposes of correctly understanding the realist argument on fetal personhood, it is critical that these three terms - "potency", "potential", and "possible" - are correctly defined, understood and not equated.  A human being with a human nature or potency is already a human being with a human nature.  It is not a "potential" human being somewhere down the line.  And it is not a "possible" human being (e.g., the woman decides not to abort, or the IVF technician decides to implant it).  As with accidental change, external circumstances do not change the very nature which is already possessed by a thing.

                Unlike several other philosophical schools of thought, this realistic philosophical argument formally defines a human being as including human matter and human powers in that definition.  It thus rejects any real split between a human being and a human person.  A "person" is part and parcel of the whole complex, concrete human being - including the human body.  "Rational attributes" are descriptive of only one of many integrated powers of that human being.  Further, the "soul" is not a thing or substance on its own;  nor does it reside in the brain, or the heart, but in every part of the whole embodied human being.  It understands that "personhood" as defined by other philosophical systems confuses "person" with "personality";  that it is theoretically indefensible and leads to rather startling conclusions (Irving, 1991, 1992;  Doran, 1989;  Wilhelmsen, 1963;  Barry, 1979). 

                Yet other scientific arguments are presented in which real existential distinctions are variously made between a human organism, a human being or a human person (Hare, 1988;  Buckle, 1990;  Dawson, 1990-A, 1990-B;  Bedate and Cefalo, 1989;  Suarez, 1990;  Bole, 1989, 1990;  Grobstein, 1985;  McCormick, 1990;  Ford, 1988;  Coughlin, 1988, 1989;  Wallace, 1989;  Lockwood, 1988;  Jones, 1989;  Sass, 1989;  Singer, 1981, 1985, 1987, 1989;  Kuhse, 1985, 1986;  Engelhardt, 1985;  Goldenring, 1982, 1985;  Kushner, 1984;  Shea, 1985;  Tooley, 1974;  Tauer, 1985;  Bennett, 1989).

                For example, it is argued that at some embryological "marker event" post fertilization a human "person" is present;  before that time there is only a human "being" present (at best).  Bedate and Cefalo, for example, have submitted sophisticated scientific arguments that at fertilization there is not even a genetic individual present, much less a human being;  "personhood" is not present until at least 14 days.  Others (e.g., Grobstein and McCormick) have argued scientifically that at fertilization there is present a "genetic" individual - but that "genetic" individuality is not sufficient for the presence of an individual human "person".  What is also needed, they argue, is the presence of a "developmental" individual, and that does not take place until about 14 days. Only a "developmental" individual can be a human "person".

                  If a writer is arguing scientifically for any kind of a real existential distinction between a human being and a human person, it should be pointed out that that science contains very specific philosophical presuppositions - e.g., scholasticism, dualism, rationalism, or empiricism.  For example, any real distinctions empirically made between a human being and a human person contain what is known in philosophical anthropology as a "mind/body split" - an historical remnant of a Platonic/Cartesean dualism grounded in a very rationalistic school of philosophy.  I will not go into the fascinating historical interplay between the reciprocal conceptual impact of philosophy and empirical science, although many have treated this matter elsewhere (Irving, 1991, 1992;  Gilson, 1949;  Crombie, 1959).  Nor will I elaborate on the history or the disasterous consequences of the theoretical problems inherent in a scholastic, rationalistic, empiricist or dualistic mind/body split in philosophy (Irving, 1992;  Fox, 1989;  Doran, 1989;  Gilson, 1963;  Eslick, 1963;  Coppleston, 1963;  Wilhelmsen, 1956;  Meilaender, 1987, 1989).  Suffice it to say that philosophically a mind/body split implies the presence of not one but rather two or more independent substances which go to make up a single human being (or a single human person).  One of a number of the theoretical problems is, of course, that if these substances are really in fact separate and independent, absolutely no interaction is possible between them.  There is literally no way that so-called "rational attributes" (e.g., consciousness, self-consciousness, autonomy, relating with the world around one, desiring, willing, loving, hating, etc.) can concretely connect with the physical "body" which is supposed to be supporting such "rational attributes".  Virtually all of the writers I will address in this paper do make such a distinction between a human being and a human person - most of them based on these types of theories of philosophy (whether acknowledged or not).

                It might be curious to scientists to see where such a rationalistic philosophy takes one even in the field of science itself.  For example, historically, one of the major philosophical sources of a mind/body split was Rene Decartes - who was both a scientist (physicist) and a philosopher.  Descartes (Edwards, 1967) defined a human being as composed of two independent substances - "Mind" and "Body" (or "Extension").  Ultimately he defined a human being as "a thinking thing" - thus one source of the so-called "rational attributes" used in many of the arguments I will address below.

                Descartes also defined the material world in terms of only one of those two substances, i.e., "extension".  Because of this definition of the material world, and because he rejected the existence of a void, Descartes' philosophical theories impacted mischieviously on his own theory of physics and his ability to even do science.  For example, because he rejected the existence of a void, the material substance of the world was therefore continuous.  This had serious consequences in his scientific theory of the vortex.  The material world is not composed of ultimate atoms, but only of volumes, which must then move as a whole, i.e., a simultaneous movement of matter in some closed curve.  Planetary motion, then, is defined as one infinite three-dimensional continuous and homogenous extended body.

                If there is only one continuous extended substance, then he can only distinguish one body from another body in terms of differential volumes and secondary qualities.  Therefore he cannot have a definition for density, or for viscosity.  Descartes also omits "matter" from his definition of motion.  Motion = speed x size - but "size" for Descartes is a continuous volume of body.  Therefore his own physical Laws of Impact are actually, empirically, in error.  He also cannot isolate a particular force (e.g., gravity) in terms of how a body would move if it were free from resistence, because to imagine it moving without resistance is to imagine it in a void - the existence of which he had rejected.

                Also, Descartes concluded (based, again, on his theory of "being", or "substance") that animals have no minds, no pineal glands (the physical organ in humans where somehow, unexplicably, the Mind and the Body are capable of interacting), and no souls.  Therefore they cannot feel any pain or pleasure, or any other kinds of sensations (sensations were only mental "modes of thought").  Since animals are only bodies, i.e., "machines", the only sense in which they can be hurt is to "damage" them.

                This rationalistic philosophical system was eventually discredited and discarded by most of the scholarly community - yet, incredibly, remnants of it remain today.  I would argue that such a rationalistic philosophical system contains such severe theoretical problems that it actually precludes one from doing either philosophy or science.  And if applied to the current issue of human embryogenesis, it is clear that such a "theory" is grossly inadequate to explain either the philosophical theories or the biological phemonena which need to be addressed.  It is clear that one cannot explain any interactions between the mind (or "soul"), and the body (or brain) of the developing human being -since they are two different substances which are separate from each other.  There can be no connection between those "rational attributes" and the "body" (or brain).   Nor can it explain the complex mechanisms of motion involved in the genetics, biochemistry and organogenesis so characteristic of human embryological development.  Nor can the embryo's or fetus' body be distinctively its own, but must be shared quantitatively with the rest of the material world.  Needless to say, however, this rationalistic philosophical theory is still used - often as paired with apparently erroneous scientific "data" - as demonstrated in many of the articles below.

Bedate and Cefalo:   Using genetics and molecular biology, Bedate and Cefalo claim that there are erroneous empirical presuppositions in the "fertilization argument."  Specifically they claim that the human zygote does not contain all of the information necessary to produce the specific biological character of the future adult (Bedate and Cefalo, 1989).  Although their arguments contain major logical, philosophical and scientific problems (Irving, 1991), I give only two examples which are particularly misleading conceptually as well as empirically incorrect.

                The development of the human zygote, they claim, depends on:

                1.  the actualization of pieces of information that originate de novo during the embryonic process, e.g., "positional information".  In support of this claim they produce the following scientific facts.  The human zygote does possess some of its own genetically coded information but not all of the molecular information needed for embryological development.  Some information is given in time through interaction with other molecules which were not coded in the genome.

                2.  exogenous information which is independent of the control of the zygote, e.g., molecular information from the mother.  In support of this claim they state that information about differentiation does not exist in the original genome.  The human zygote contains only enough genetic information to proceed through the blastocyst stage, and does not contain the information for the process of differentiation.  Rather, the information for the process of differentiation is determined and derived by an exchange of information originating in the mother.

                  There would seem to be several problems with their first claim.  First, there is an equivocal and misleading shift in their use of the critically important term "information".  "Information" can mean genetic information, or molecular ("positional") information.  The fertilization argument is not a claim that virtually all of the information - genetic as well as molecular - is present at fertilization.  Neither at fertilization nor at the age of 45 years do any of us contain all of the molecular or positional information we will ever have.  But that is not the point.  At fertilization a human zygote does contain virtually all of the genetic information the human being ever will possess.  No new genetic information is gained during embryogenesis - and none is lost.  As Jerome Lejeune, the internationally recognized developmental geneticist, has put it for the non-scientific audience:

...each of us has a unique beginning, the moment of conception... As soon as the twenty-three chromosomes carried by the sperm encounter the twenty-three chromosomes carried by the ovum, the whole information necessary and sufficient to spell out all the characteristics of the new being is gathered...  (W)hen this information carried by the sperm and by the ovum has encountered each other, then a new human being is defined which has never occurred before and will never occur again...  [the zygote, and the cells produced in the succeeding divisions] is not just simply a non-descript cell, or a "population" or loose "collection" of cells, but a very specialized individual, i.e., someone who will build himself [i.e., possesses the nature or potency] according to his own rule.  (Lejeune, 1989) (emphasis added)

Lejeune's description is likewise expressed in more scientific terms in virtually all embryology and genetic text books known to this writer.

                Second, this original genetic information in the human zygote will itself specifically direct the formation of virtually all of the molecular or "positional" information necessary for the continuous development of the human zygote to the human adult.  This is explained empirically in part by the process of methylation, a process which is itself encoded in the original genetic information of the human zygote.  Methylation is one factor which explains why some genes are "silenced" and other genes are "turned on" during development (Lejeune, 1989), producing what Lewin describes as a process of "information cascading" (Lewin, 1983;  Emery, 1983).  These processes - which continue into adulthood - help to explain both genetic as well as molecular levels of developmental control.

                In describing the process of cascading, Lewin explains how information is transmitted from the human zygote to virtually all of the later stages of development:

"We view the development of an adult organism from a fertilized egg as following a predetermined pathway, in which specific genes are turned on and off at specific times... (W)e see that the product of one gene may control another gene.  A cascade of control ensues when a series of such events are connected so that the gene turned on (or off) at one stage itself controls expression of other genes at the next stage"  (Lewin, 1983). (emphasis added)

                In addition to gene control, cascading also accounts for molecular control.  For example, Lewin states, products of genetic instruction, such as protein molecules, carry within themselves certain "instructions" by virtue of the kind of molecules they are.  Thus proteins exhibit a diversity of forms.  There are primary, secondary and tertiary forms of a protein.  There is also, we know, a relationship between the structure of a protein and the way it functions (Lewin, 1983).  How do these different conformations of a protein come about?

                As Lewin further explains in his text, it is a "fundamental principle that higher-order structures are determined directly by the lower-order structures.  This means that the primary sequence of amino acids carries the information for folding into the correct conformation."  And this control continues in a "sequential folding mechanism" through the higher-order levels of organization.  "All the information necessary to form the secondary structures resides in the primary structure" of the protein.  And the primary structure of the protein is determined by the genetic information in the cell.  Lewin continues that the "structural, catalytic, and regulatory activities of the proteins of a cell are responsible, directly or indirectly, for creating its ultrastructure and interconverting the small molecules... Obeying the laws of physics and chemistry, together these macromolecules are responsible for the survival of living cells (Lewin, 1983).

                Thus - if this scientific account is correct - the claims of the fertilization argument would seem to be correct, and Bedate and Cefalo's scientific claims would seem to be incorrect.  All of the genetic information is present at fertilization which is needed to produce the specific biological character of the future adult, including specifically human "positional" molecules, as well as specifically human tissue and organ systems.  This genetic information controls both genetic and molecular information which "cascades" throughout all of a human being's development.  Later "positional" molecules, reactions and organ formations of the developing human being are not random or independent of the human zygote's genetic content and structure, but are ultimately generated, controlled and coded by that very genetic information present in the original human zygote.

                Bedate and Cefalo's second argument, that the development of the human zygote depends on "exogenous" information from the mother which is independent of the control of the human zygote, is likewise conceptually misleading and, it would seem, scientifically incorrect.  First, I again point out their equivocal use of the term "information".  Their argument is about molecular information - not genetic information.  And, as implied above, even the use of exogenous "positional" information is pre-determined by the genetic information in the original human zygote.  Second, their claims that the human zygote only contains enough of its own genetic information to proceed through the blastocyst stage, and that the process of differentiation is not coded in the genetic information in the human zygote but rather is determined by "information" from the mother also seems to be scientifically incorrect.  It would appear clear from Lejeune, Lewin, Emery and most other well-established and respected scientific authorities that the original human zygote does indeed contain all of the genetic information  needed for all of the processes of human development - including those of cleavage, cell differentiation, and implantation.  Furthermore, there are many recent experiments, especially those involving transgenic mice, which would refute Bedate and Cefalo's empirical claim that the process of differentiation is determined by the mother (Mavilio, 1986;  Hart, 1985; and Holtzer, 1985; see also Suarez, 1990;  Szulmann, 1978;  Moore, 1982;  Wimmers, 1988;  Lawler, 1987;  Martin, 1980;  Alberts, 1983).

                Also, it would seem that Bedate and Cefalo's claim about the source of the information for differentiation is closely connected to another error, i.e., a misconception about human "development."  Their implication is that human development is somehow informationally and physically discontinuous.  It would seem that human development is controlled essentially at one time by "information" from the zygote, embryo or fetus, and at another time by "information" from outside and independent of the developing human being.  But the most reliable scientific sources indicated above claim that the essential nature and genetic information of the product of fertilization, i.e., the human zygote, itself determines continuously the essential course of human development.  Exogenous molecules contribute only accidentally.  There is, scientifically, no controlling informational or physiological break from the original human zygote during all of human development. 

                Thus, according to this science, the human zygote is by nature and by definition a human being, possessing "46" chromosomes and the active genetic capacity (including mitochondrial DNA) to change itself over time in accidental - not essential - ways.  There is no biological, genetic or informational break in this developmental continuum.  Exogenous molecular information - even from the mother - does not actually change the very nature of the developing human being, i.e., change it from one kind of thing into another kind of thing.  Empirically we know that that is not what happens -all we have to do is look at the number and kinds of chromosomes present from the beginning and throughout human development.  An embryo does not have the number and kinds of chromosomes as a tomato plant;  nor does the fetus have those of a giraffe.  Maternal molecules do not determine the very nature of the developing human being nor the nature of its processes.  Maternal molecules are only used in non-essential accidental processes of human development; and that use is itself dictated ultimately by the genetic and molecular information in the human zygote, embryo or fetus.

                There is also the implication by Bedate and Cefalo that "development" is restricted to the embryonic and fetal stages.  But unrefuted work by the embryologist Moore - among many others - would reject such speculations concerning this and the above points.  Unless the text books of Moore, Lewin, Emory and other well-known and generally accepted and acknowledged scientists, as well as multiple recent works in journal publications, are grossly incorrect, the most accurate and reliable description of embryological development is as follows (and I quote from Moore):

Human development is a continuous process that begins when an ovum from a female is fertilized by a sperm from a male.  Growth and differentiation transform the zygote, a single cell formed by the union of the ovum and the sperm, into a multicellular adult human being.  Most developmental changes occur during the embryonic and the fetal periods, but important changes also occur during the other periods of development:  childhood, adolescence, and adulthood... Although it is customary to divide development into prenatal and postnatal periods, it is important to realize that birth is merely a dramatic event during development resulting in a distinct change in environment.  Development does not stop at birth:  important developmental changes, in addition to growth, occur after birth...  Most developmental changes are completed by the age of 25.  (Moore, 1982, p. 1) (emphasis added)

                And finally, Bedate and Cefalo have argued that the developing entity is not predetermined to give rise to a human being, since it can give rise to biological entities that are not human beings, i.e., hydatidiform moles and teratomas.  However, as Suarez (1990) correctly points out, the empirical implication in that argument is that hydatidiform moles and teratomas develop from biologically normal embryos - but that scientific implication is apparently scientifically incorrect.

                As Suarez argues, hydatidiform moles do not develop from something which is normal, but from biological entities which carry gross chromosomal aberrations, and thus possess no capacity at all to function biologically as a human being or to develop into normal human beings.  Hydatidiform moles of the complete type (CHM) arise from androgenic eggs (i.e., eggs with two paternal nuclei).  The usual mechanism is the fusion of an egg and sperm followed by duplication of the sperm genome and loss of the female nucleus.  Sometimes the mechanism is due to dispermy (i.e., two sperms enter the egg at fertilization) with the loss of the female nucleus.  Either way, Suarez explains, hydatidiform moles do not originate from normal human embryos, but rather from entities containing either no maternal chromosomes or from entities containing two paternal chromosomes.

                Suarez also points out that ovarian (gynogenic) teratomas can arise from parthenogenesis.  That is, without fertilization by a sperm, an egg in the ovary can cleave spontaneously, and progress to form a morula and then a blastocyst.  But it then becomes disorganized and divides into a tumor.  Male (androgenic) teratomas can arise spontaneously from only the male germ cells in the testes.  The empirical point is that in neither the case of the formation of a hydatidiform mole nor of a teratoma did these biological entities arise from a genetically normal human embryo to begin with.

Grobstein and McCormick:   These writers (Grobstein, 1985;  McCormick, 1990) argue that a human person can be present only if there is a "developmental" individual, rather than simply a "genetic" individual.  The 5-6 day stage of embryological development is significant for them because at this point they claim that they can demonstrate scientifically the presence of "only a genetic individual" (i.e., not a "developmental" individual) - a non-person.  They will term this entity a "pre-embryo", implying it is a "pre-individual", or a "pre-human being".  

                These writers state that at the 5-6 day stage, two cell layers are formed - the trophoblast or outer cell layer, and the blastocyst or inner cell layer.   McCormick, following Grobstein, makes this empirical argument:

I contend in this paper that the moral status - and specifically the controversial issue of personhood - is related to the attainment of developmental individuality (being the source of one individual)... It should be noted that at the zygote stage the genetic individual is not yet developmentally single - a source of only one individual.  As we will see, that does not occur until a single body axis has begun to form, near the end of the second week post fertilization when implantation is underway.  (McCormick, 1990) (emphasis added)

These early cells, they claim, are really only "loose collections" of undifferentiated, "totipotent" cells, and they name them, or designate them collectively, as only comprising a "pre-embryo" (a term which is not used by other embryologists, but only by philosophers, theologians and bioethicists).

                The scientific facts which they give to support these claims are the following.  They state that only the cells from the inner layer, the blastocyst, eventually become the adult human being.  The cells from the trophoblast layer, they write, are all discarded after birth as the sac and the umbilical cord, etc.  Thus, developmentally, the implication is that we are not dealing with a developmental individual, or only with those important cells which will become the adult human being, i.e., the blastocyst, but rather a mixture of "essential" (blastocyst) and "non-essential" (trophoblast - will all be discarded after birth) cells, i.e., a PRE-embryo.  A pre-embryo, then, is not a human being or a human person, yet:

This multicellular entity, called a blastocyst, has an outer cellular wall, a central fluid-filled cavity and a small gathering of cells at one end known as the inner cell mass.  Developmental studies show that the cells of the outer wall become the trophoblast (feeding layer) and are precursors to the later placenta.  Ultimately, all these cells are discarded at birth.  (emphasis added)

                These scientific facts would seem to be incorrect, and would necessarily lead to incorrect philosophical concepts, as well as erroneous ethical judgments.  It is scientifically incorrect to state that all of the cells from the trophoblast layer are discarded after birth.  As can be found in virtually all embryology texts, including Moore's text from which they quote, many of the cells from this trophoblast layer become an integral and essential part of the constitution of the fetus, newborn and adult human being.  For example, the cells from the trophoblast layer known as the yolk sac cells become part of the adult gut.  And cells known as the allantois cells become part of the adult ligaments, blood cells and urinary bladder (Moore, 1982;  Chada, 1986;  Migliaccio, 1986).  Unless these latter sceintists are incorrect, empirically these claims by Grobstein and McCormick cannot be scientifically sustained, since many of the cells from the trophoblast layer are developmentally and genetically continuous with the adult human being.  The 5-6 day stage human embryo, then, is both genetically and developmentally individual and one with the future human adult.  It would seem that their term "pre-embryo" and what it implies can not be sustained with the scientific information which they have stated to support their claim.  It would also seem that the moral status to which they refer should be the same for the 5-6 day embryo as the adult - since they are both developmentally individuals and in fact are literally the same individual organism at different accidental stages of development.

                It is interesting that they agree that the early cells up to the 14 day stage (the "pre-embryo") do comprise an "individual" - albeit, only a "genetic" individual.  Why does this "genetic" individuality not suffice for characterizing it as a "being" or substance?  They simply posit that before a human "being" can become a human "person", it must be the source of only one individual, and developmentally that "oneness", they say, is not guaranteed until after 14 days.

                But why should "being the source of only one individual" be such a critical criteria for moral status?  One could argue that first there is one individual worthy of moral status, and if twins or triplets result later, then there are two or three individuals worthy of moral status.  If it is an individual, it is an individual.  Also, since virtually all of the "developmental" stages are normal processes programmed by the genetic information in the original human zygote, what would make the developmental stage of "implantation" (which they designate as that stage where the developing human embryo can now be "the source of only one individual") any more significant than any other developmental stage?  Indeed, as others will argue below, why not call the developmental stages of "sentience" or of "whole brain integration" the morally relevant stage?  Others have argued convincingly against McCormick's and Grobstein's interpretation of and arguments for such a concept of "developmental" individuality (Fisher, 1991;  Howsepian, 1992).  But empirically, is implantation really in fact such a definitive developmental stage such as to preclude "the source of more than one individual"?

                Grobstein and McCormick will provide more scientific evidence in order to ground their claim that at 14 days a "developmental" individual, i.e., a person, is finally present.  It is impossible, they claim, for a human person to be present until at least the 14 day marker event (implantation), at which point the primitive streak forms in the embryo.  The philosophical significance of this marker, they state, is that until the formation of the primitive streak it is possible for twinning to take place.  The totipotent cells "do not yet know whether to be one or two individuals."  After 14 days, they claim, twinning is not possible, and thus the organism is finally determinantly one individual - an essential pre-requisite for "personhood"  (McCormick, 1990).

                But again this science seems to be incorrect.  As Karen Dawson (1990) and Moore (1982) point out in these debates - and as is found in every human genetics textbook (unless they are wrong) - it is possible for monozygotic twinning to take place after 14 days and the formation of the primitive streak.  For example, fetus-in-fetu twins can be formed up to 2 and 3 months after fertilization, and Siamese twins even later.  It is also known that "twinning" is sometimes genetically determined and coded in the original single-cell human zygote (as, indeed, is totipotency, differentiation and implantation).

                And is it empirically true that these totipotent cells "do not yet know whether to be one or two individuals" yet?  Is it that they are traumatically so "undecided"?  Of course if a totipotent cell is teased apart (mechanically or from natural circumstances) from the early developing human being, it can develop into an adult-stage human being.  But this phenomenon is normal!  That is, totipotency is programmed into the single-cell human zygote just as all of the characteristically human developmental stages are.  According to nature, during totipotency these cells are supposed to be totipotent.  It would not seem to have anything to do with these cells being somehow "unnatural", "unhuman" or confused and undecided. 

                Thus Grobstein and McCormick's scientific claims to ground both the presence of a pre-human, pre-person, pre-developmental "pre-embryo" at 5-6 days, as well as a 14 day implantation stage of "personhood", seem to be scientifically incorrect.  And so also must their philosophical and moral claims about individuality and "personhood" which are grounded on the science they used to support their claims.

                Just as empirical data can impact on philosophical concepts and moral judgments, such philosophical concepts and judgments (containing scientific statements) can impact on theology.  Specifically, many theologians require "individuality" as a prerequisite for "ensoulment".  Such, in fact is the case with McCormick.  In what follows I will address several other theologians whose concepts and arguments for ensoulment have been grounded in what seems to be incorrect scientific facts.

Suarez (1990), for example, argues that ensoulment must take place at the 2-cell stage, when there is the completion of the first cell division, as well as the completion of the genetic input.  However, we know scientifically that the completion of the genetic input is at the single-cell zygote stage, and that that genetic imput is what directs cell division to begin with.  Thus, based on these scientific facts, Suarez should be arguing for ensoulment at the zygote stage, rather than at the 2-cell stage.

Ford:   Based on the science of Grobstein and McCormick, Ford (1988) also argues for ensoulment at the 14 day stage (although, before the advent of Grobstein and McCormick's scientific arguments, Ford had argued for ensoulment at fertilization - Ford, 1987).  Before 14 days, Ford explains, there is only a biological individual;  after 14 days there is an "ontological" individual, i.e., when differentiation is completed and there is a "distinct individuality".  But aside from the apparent problems with the science of Grobstein and McCormick, as well as their conclusions about "individuality", we know scientifically that complete differentiation does not actually take place until well after birth (Moore, 1982).  Certainly a 14 day embryo is definitely not completely differentiated.

Bole:  Bole (1989, 1990), contra Suarez, accepts the scientific data as offered by Bedate and Cefalo.  He agrees that the zygote is not yet an individual, is not specifically human, and is not responsible for developmental or differential information.  He also accepts their conclusion that the human zygote cannot be a human being, and therefore it cannot be a human person.  Thus he makes a distinction between a mere "biologically integrated whole" (a non-person) and a "psychologically integrated whole" (a person).  Ensoulment, for Bole, cannot take place until there is an appropriately organized body - a criteria which is not met by a mere "biologically integrated whole."  Only a "psychologically integrated whole" can be an ensouled human person (Bole, 1990).  But what, for Bole, is a human person?

                To answer this, Bole (1990) moves into the philosophical arena, searching historically for a philosophical system (or any parts of philosophical systems) which would match the scientific arguments of Bedate and Cefalo.  I will not expand on his interesting historical search, other than to relay Bole's conclusion, that a "person" is to be defined much as Engelhardt has defined a "person", i.e., as that which can:

...unify experiences as its own and reason about connections not only between experiences and their unifying self and between action and goals, but also about the connections between actions, whether to or by this person, and the personal agent to be morally blamed or lauded for them.  Such a person might begin to be instanced in a young child who can use "I" and can blame those who would injure it.  (Engelhardt, 1985) (emphasis added)       

Thus, convinced of the scientific arguments of Bedate and Cefalo, and finding a "match" with the rationalistic philosophy of Engelhardt, Bole concludes that the term "person" would be applied to competent adults, and younger human beings who can sufficiently use languages, i.e., "can unify their experiences in self-consciousness as their own, and reason about connections between actions and ends."  A fetus or a normal young infant is only a biologically integrated whole.  They are not "persons".  They are only "substances".  And a human zygote is not even a human substance - although, he claims, that it is a human being (Bole, 1990). 

                Without going through all of the philosophical details, it is important at this point for the scientific community to understand what is at stake, i.e., what are the conceptual and very real consequences when a human "person" is defined only in terms of reason or "rational attributes", such as is found in Bole (1989, 1990), Engelhardt (1985), Singer (1981, 1985, 1989), Kuhse (1985, 1986), and Tooley (1974).  If only a "person" is due moral, social and legal protections and priviledges, and if a "person" is defined only in terms of the actual exercising of "rational attributes", then the majority of human beings are not persons, and therefore are not protected.  That is, the mentally infirm, drunks, alcoholics, drug addicts, Alzheimers and Parkinsonian patients, stroke victims, the depressed, etc. are not "persons", and therefore bear no moral, social or legal rights or protections of their own.  Even the killing of normal healthy human infants and young children (infanticide) is morally acceptable to these writers.  As Singer, the animal rights theorist, has put it:

Now it must be admitted that these arguments [about abortion] apply to the newborn baby as much as to the fetus.  A week-old baby is not a rational and self-conscious being, and there are many non-human animals whose rationality, self-consciousness, awareness, capacity to feel pain (sentience), and so on, exceed that of a human baby a week, a month, or even a year old.  If the fetus does not have the same claim to life as a person, it appears that the newborn baby is of less value than the life of a pig, a dog, or a chimpanzee.  (Singer, 1981) (emphasis added)

Such are the very real and serious consequences of accepting this rationalistic definition of a human person.

                Finally, Bole will also redefine some important embryological terms, based on the science of Bedate and Cefalo.  By the term "zygote" he will now refer to the product of fertilization to 14 days.  Before 14 days the "zygote" is not a human being, since it is not a "biologically integrated whole."  The term "embryo" he reserves for the entity from 2-8 weeks.  I have to wonder how many embryologists would agree with Bole's new biological nomenclature.  Given the apparent incorrectness of the scientific arguments of Bedate and Cefalo, and the massive inadequacies in the "matching" rationalistic philosophical definition of a human "person", can Bole's arguments or distinctions hold up?

Wallace:   "Based on recent research in reproductive biology, especially on studies of cell division, twinning, recombination and implantation", Wallace (1989), a physicist, also sees a need to up-date the scientific foundations of a scholastic philosophy of nature which can account for ensoulment (often placed at about 3 months).  I would argue that Wallace sees a parallel between McCormick's "pre-embryo" which seems to be in transition to becoming a "person" at 14 days, and what the scholastics called a "being on the way", or a "seed".  I will present his scholastic philosophical concepts and arguments only long enough to be able to pull out a few of the incorrect scientific claims and invalid scientific analogies which he uses to make his point.  Wallace, who is a physicist and a scholastic philosopher, will attempt his own redefinition of human embryogenesis.

                One philosophical comment is in order to clarify Wallace's (and others') concern about "ensoulment".  If the "soul" is considered as a whole thing itself (i.e., a substance or a being), then a theory of "delayed hominization" (delayed "personhood") is necessary to explain how all the different and separate component substances of a human being get put together serially somewhere down the line (an example of a mind/body split).  However, if the "soul" is considered as only a principle, a power, or as a part of only one whole thing, and if the vegetative and sensitive powers of the soul cannot be separated from the rational powers but are contained in it virtually, then there is simply no need for a theory of delayed hominization.  Instead, a theory of immediate hominization (immediate "personhood" at syngamy) is necessary.  I point this out because, interestingly, Wallace's and others' rationalistic philosophical commitment requires the kind of "science" such as reported by Bedate, Cefalo, Grobstein and McCormick.  Is it possible that these philosophical presuppositions are imposed on the scientific data?  (The subject of another paper.)

                  Wallace's project is roughly the following.  First he will describe what he calls stable natures: inorganic materials, plants, animals and finally human beings.  These descriptions, he says, are true only of the mature individuals - not of those individuals as they were being generated.  Second he will describe what he calls transient natures, such as radioisotopes.  It is the model-concept of these immature transient natures which he will use to redefine human embryogenesis.  Each of the grades of stable natures will be considered (invalidly) like a transient nature during the process of human embryogenesis. They will be successively "educed" from the "protomatter" of the previous transient nature (which has eventually become stablized).  This is how it works.

                The "mature" stable natures are exemplified by the following.  First, an inorganic nature, (e.g., a chemical element, a compound, or a mineral) is an organizing field, a force which structures "protomatter" and gives it certain qualities and powers.  Second, a plant nature contains these inorganic powers, as well as its own vegetative powers, e.g., nutrition, growth, reproduction and homeostasis.  It is the growth power which is the developmental power, controlling cell growth and differentiation.  Third, an animal nature contains the two previous powers, plus its own, e.g., the powers of sensation and emotion.  All of these lower forms are educed from "protomatter" by angelic activity and are material forms.  Fourth, the human form, being immaterial, is created by God, with the powers of intellect and will.  These human powers do not need any body organs through which to operate.

                The "transient" natures he will describe will "explain the efficient causality we observe during fetal development".  He likens these transient natures to the "seeds" which so puzzled the medieval scholastics.  He calls these natures "transient" because they have only fleeting or transitory existence.  Also of importance is how these "transient natures" are generated (which he will also liken to fetal development).  "Transient natures" are generated through an "eduction" of a form from something which contains many forms potentially;  then it will receed back into the "protomatter", and be replaced by another form which will be "educed".  When this happens, he explains, substantial - not accidental -change has taken place.  For example, there is the generation of compounds from elements.  Na and Cl combine to form NaCl.  When they so combine, Wallace claims, the Na and the Cl have actually changed their natures, and have become a third nature - i.e., NaCl.  Thus in the formation of elemental compounds, "when the new nature is generated the old nature ceases to be."  He will use this "model" analogously to argue for delayed hominization.  That is, during early embryogenesis, there is literally substantial change taking place - i.e., a change in natures.  First there develops a human "vegetative" substance or nature, replaced by a human "sensitive" (or animal) substance or nature - which is finally replaced by a human "rational" substance or nature.  

                However, when the reverse of such a process is explained - e.g., the decomposition of water -Wallace himself is puzzled.  Why does the decomposition of water result in two hydrogens?  This poses the probem of "individuation" to him (Wallace is puzzled because his philosophical definition of "natures" consists only of the universal "species" form, and thus it can not explain the materiality of the individuals which comprise the "species").  So he trys to liken the two hydrogens to identical twins - but cannot resolve the puzzle, if theoretically what is generated is the universal "species" only.  He will not let this theoretical problem daunt him, however, and takes refuge in what he considers to be a chemist's response.  "For chemists it is sufficient to consider the nature apart from the individual, since in their view all hydrogen molecules are necessarily the same" (emphasis added).  So Wallace is free now to consider only the nature, apart from the material individuals - a prerequisite, interestingly enough, for a theory of delayed hominization.

                Wallace's next example of a transient nature comes from radiochemistry.  He describes the radioactive decay of one element into another.  And like the human embryo, he claims, the parent isotope is "self-activating".  Here, each of the daughter isotopes is successively "educed" from within the potency of the parent isotope.  Although he thinks that this model of radiochemistry is really descriptive of a stable nature, he states that he will "consider" it as a transient nature anyway, because it is useful to explain human embryogenesis.

                And finally, Wallace will apply his model of "transient natures" - based on recent research in reproductive biology - to describe his own theory of human embryogenesis, or the serial generation of a plant, to an animal, and finally to a human being.  Wallace's description of human embryogenesis involves a constant progression from a transient nature to the stable form of that nature, from which is educed the next transient nature which likewise persists until the stable form of that nature appears, etc. 

                First, then, human embryogenesis begins with the seeds (ovum and sperm) of the human parents.  These seeds combine to form an entity with a "plant-like" transient nature [he means the human zygote].  "When material defects are eliminated and twinning or recombination can no longer occur", a new stable-like plant form is educed from the potentiality of the "protomatter", with its own proper "plant" powers.  This stable plant form persists until a new transient animal-like form is educed.  Again, when material defects are eliminated and twinning or recombination can no longer occur, the new stable animal form with its proper powers is educed.  Finally, when this animal "matter" is appropriately organized by the animal form, God creates the immaterial human form (i.e., the "rational" soul alone) with its own proper powers - and we now have a human being with human ensoulment completed (i.e., a human "person").

                The problems with Wallace's redefinition of human embryogenesis are both conceptual and scientific.  I will list but a few.

                1.  Empirically there is no such thing as two kinds of natures of one and the same specific kind of thing.  That is, there is no such thing as a "transient" nature and a "stable" nature of a plant or of an animal - nor of a human being.  One only has to check the chromosomes to determine that.  An acorn is genetically an oak - albeit a tiny one.  That is why it can grow into the stage of a large oak tree, instead of becoming a pumpkin.

                2.  It is invalid for Wallace to claim that there is an analogy between "stable" natures which are descriptive of mature individuals only, and his serial "phases" of "transient" natures during the immature stages of human embryogenesis.  After going through his paradym example of a "transient" nature, Wallace will then admit that a radioisotope is probably really an example of a "stable" nature -but he will use it anyway as a "model" of his so-called "transient" natures during human embryogenesis.  If it is really a "stable" nature, how can he legitimately use it as a substitute "transient" nature in his model of human embryogenesis?  He even admits the inconsistency, but decides to use the analogy anyway, without any argument - other than that it is "useful".

                3.  Relatedly, if the "rational" human nature which is infused at about 3 months is actually descriptive of a "mature" human nature, would Wallace then agree that a three month fetus which was receiving this mature human nature was actually a mature human being?

                4.  Simply because Wallace's "transient" natures (e.g., radioisotopes) have a "brief" existence does not mean therefore that they are not stable natures.  An existent is an existent - no matter how briefly it exists.       

                5.  As a chemist, I cannot imagine any other chemist who would agree with Wallace that Na and Cl actually change their very natures when they form a compound.  There is only the sharing of electrons - not protons.  Nor would a chemist agree that all hydrogens are the same;  chemists know about natural isotopes.  The atomic weights given in the periodic chart are only an average weight for the elements.  Nor would they accept Wallace's analogy between the generation of "daughter" isotopes from radioactive "parents", and the generation of a human zygote from two human parents.  The radioactive "daughter" is a different "species" than the "parent";  the human zygote has the same number of chromosomes as the human parents and is of the same species.

                6.  Wallace invalidly compares and equates several different scientific terms and processes.  For example, the "nuclei" of a radioisotope and that of a plant, an animal, or a human cell are hardly equivalent.  Nor is the "generation" of any of those entities equivalent.  He also uses an incorrect analogy between a plant "seed" and human "seeds" (the ovum and the sperm).  A plant seed already contains all of the reproductive information it needs to develop;  a human ovum or sperm contains only half of the necessary information.  Thus if only a sperm or only an ovum were implanted in a womb, no human being would ever result from it.  The more correct empirical correlate, actually, would be between the plant seed and the human zygote after syngamy.

                Wallace made a critical observation during his paper which might have kept him out of the above difficulties.  He noted one of the classic insights of both bench research science and of a realistic philosophy of nature:  "... a quality is an attribute through which we come to know a nature.  A thing's actions and reactions enable us to ascertain its powers and from these we judge its nature".  Every bench researcher, I would argue, is quite familiar with this truth of basic research.

                Had Wallace only adhered to his own astute observation it would have precluded him from developing his model of "transient" natures which he wanted to use to explain human embryogenesis.  For if one looks hard at the most agreed upon scientific evidence which we do have, Wallace would have had to argue for immediate hominization.  Biologically we know that at syngamy there is already a human being with "46" chromosomes;  that immediately there are specifically human enzymes and proteins produced (not tomato or frog enzymes);  that all of the information for cleavage, totipotency, implantation, etc., is already present;  and that by "3 months" specifically human functions, reactions, tissue and organ formations have already taken place.  Empirically, the formation of cabbages or giraffe tissues and organs has not taken place.  There is, then, no need biologically for a "rational soul" to be infused at three months to make it specifically human and direct human formation.  That work has already been done by "something" back at the human zygote stage.  The 3 month fetus doesn't need a rational "soul" (which for rationalists doesn't even contain a vegetative or a sensitive "soul") to make it something it already is - a human being which is functioning humanly.  This biology would enable us to ascertain its human nature and would argue for immediate hominization.  It compells us to reject a real mind/body split.

II.  Philosophy/Theology/Biomedical Ethics:  "Later" Fetal Development

Although the above writers have used scientific facts concerning cell differentiation, implantation, twinning, etc., as either an argument against syngamy or for the "earlier" marker events of "personhood", the remaining commentators have abandoned these early stages as being insignificant.  Instead they will use scientific data to argue for some sort of brain-related marker, based on the later stages of human embryogenesis.  Regardless if they will argue that "personhood" requires the presence of "rational attributes", or sentience (the ability to feel pain), the focus of their arguments is the physiological substrate which they claim is the pre-condition for either of those characteristics of personhood.

                All of these writers have several problems in common, so for brevity I will state these beforehand, as they apply to all of the writers generally (see Irving, 1991).

                First,  many will still actually define a human "person" in terms of "rational attributes" only.  But as pointed out above, this is a very rationalistic definition drawn from a philosophical theory with a mind/body split.  Thus there can be no interaction between the physiological substrate for which they argue and the "rational attributes" which those physiological substrates are suppose to be supporting.  Others will define a human "person" in terms of "sentience" only.  But this is a very materialistic definition drawn from a philosophical school of thought which also has very serious theoretical problems of its own.  No where do these writers either acknowledge their own philosophical presuppositions or argue for their respective definitions of a human being or a human person.

                Second, the physiological substrate which is a precondition for the physiological substrate for either "rational attributes" or for sentience is the human zygote itself. 

                Third, in none of their markers is there any real "personal" functioning at all.  These stages are all immature stages, and as other writers have indicated, "full consciousness" or "full physiological integration" or sentience is not complete until well after birth.  All of these arguments, then, are arguments from "potential".

                Fourth, the scientific evidence for these claims is still very sketchy, vague and controversial.  Many scientific critics indicate a reading into the scientific evidence more than is either physiologically or conceptually possible.

                Fifth, conceptual parallels are often made on which to base distinctions, e.g., evolution theory or the criteria of "brain death".  None of these parallels are argued for but are simply posited.  Only the similarities are noted;  the differences, which could actually contradict the existence of any such "parallels", are ignored. 

                As a quick survey of the literature reveals, one of the writers who argues for brain-related criteria is MacKay (see Jones, 1989).  The maturation of the nervous system is the significant stage (before that point there is only a "no one" there).  Rahner, Ruff, and Haring (see Jones, 1989) claim that the evolution of "persons" parallels the evolution of the cosmos.  That is, there is a major leap in embryogenesis with the "evolution" of the cerebral cortex at about 20-45 days.  Several British writers (see Jones, 1989) argue for 40 days with the functioning of the nerve net.  This point, they state, parallels "brain death", implying that "consciousness" is the defining characteristic of a human person.  Humans are to be defined in terms of a nature able to exercise rational, moral and personal capacities.  Since the first moments of the conscious experience is the basis for later rational and moral thought, they claim, these conscious experiences are dependent on the development of a functioning nerve net.  Sass (1989) argues for 54 days - what he calls "brain birth", or Cortical Life I (his parallel to "brain death").  He bases his position on its compatibility with the medical understanding and explanation of the process of human embryonic development and gestation.  Singer and Wells (see Jones, 1989) argue for 6 weeks, because consciousness, autonomy and rationality are morally relevant characteristics, consciousness being the most minimal.  At 6 weeks a being is capable of feeling pleasure or pain (sentience), or of having experiences and preferring some kinds of experience to others.  At that point the being has special moral status.  And Tauer (1985) argues that a "person" emerges with brain activity at about 7 weeks.

                Several writers argue for the 8 week biological marker.  Lockwood (1988) and Goldenring (1982, 1985) see this stage as the starting point for human "personal" existence because this is the point at which there is integration of the brain as a whole.  Goldenring considers this view persuasive because of the symmetrical view it offers of the beginning and end of human existence, and because of its objective basis.  Kushner (1984) argues that consciousness depends on the functioning of the brain at 8 weeks.  Shea (1985) considers this the time when the newly developing body organs and systems begin to function as a whole under the direction of a functioning brain.  Grobstein (1985), in another article, also argues that at 8 weeks there is a person.  He states that the beginning of "life" is not significant, but rather the manifestation of "self" (pace Engelhardt).  Until 8 weeks, he argues, the human embryo lacks the two essential aspects of personhood:  affective recognizability by other people, and internal conscious awareness.  And Gertler (see Singer, 1981) argues that 5 months is the proper marker, when "brain birth" begins.  Human cognition, he claims, is distinctive of "persons", and is indicated by the beginning of the formation of EEG waves in the neocortex around 5 months.  Bennett (1989) also argues for "brain life".

                There is, however, no scientific evidence which demonstrates the correlation of "consciousness" and the organizing of the nervous system, as pointed out, for example, by the Board for Social Responsibility (1985) in London.  And many writers, such as Jones (1989), have argued that the parallelism between brain death and brain life is invalid.  Brain death, he points out, is the gradual or rapid cessation of function of a brain.  Brain birth is the very gradual acquisition of a function of a developing neural system.  Jones argues that this developing neural system is not a brain.  He also questions the entire assumption, and asks what neurological reasons there might be for concluding that an incapacity for consciousness becomes a capacity for consciousness once this point is passed.  Also, the nervous system of the eight-week old fetus is quite different from that of the seven or eighth month old fetus, let alone that of the two-year old child.  The nervous system of the eight week old fetus, Jones argues, is not a miniature version of the young child's brain.  It is very incomplete, and its functioning is at a different level from that of the late fetus or young child.  What follows from this, Jones adds, is that at present it is impossible to recognize a distinct point of transition from a "non-brain" to a "brain", or from a non-functioning nervous system to a functioning one.  He also argues that it is impossible to recognize a distinct point of transition from a "non-person" to a "person".  Indeed, as Jones points out, all of these sorts of arguments are in fact arguments from "potential" - arguments which these very writers are suppose to be arguing against:

The second theme for some of the writers is the crucial part played by the appearance of the cerebral cortex.  The rationale for this is that it is the cortex which, in the postnatal human, is central to higher thought processes.  While there is no denying that this is the case later on in life, the issue during early gestation is whether the first appearance of cortical progenitors signifies that the fetus has personhood or a personal center of life.  The features associated with personhood in postnatal life are only potentially present in the eight week fetus;  and so this stance relies upon the potentiality argument.  Surprisingly, though, this is not brought out by these writers.

                Jones also examines the parallel that is made between these early neural structures and sentience, or the capacity to feel pain.  The earliest that immature EEG activity can be obtained in very limited areas of the cerebral hemispheres is 14 weeks.  Even this responsiveness to pain is poorly localized at this stage.  This is problematic in that the initial time of electrical activity appearing in the fetal brain is of an amorphous nature and thus difficult to determine with precision.  And with regard to pain, there is no way of knowing whether a behavioral response we would experience as pain is experienced in the same way by an early fetus with a rudimentary nervous system.  In view of these data, Jones concludes, it is difficult to have any assurance that specific developmental stages can be associated with concepts such as "differentiation" or "integration".  Neither can one assert that "there is 'conscious awareness' from the eighth-week stage onward".

                Jones, himself, will argue for "brain-birth" at 6-7 months, a position which would seem to be problematic too, given all of his own criticisms of arguments from potentiality, the immaturity of the biological systems and the dis-symmetry between the concepts of "brain death" and "brain birth".  The situation calls to mind the remarks of a different Jones' (1987) concerning the role of the scientist in these disputes about fetal "personhood":

The reproductive biologist cannot assign moral status to the sperm or the egg or the fertilized egg or any of the subsequent products that may result from this fusion... The reproductive biologist can help, however, by assuring that other scientists or those who wish to assign a moral status - and use a biological term or concept to do so -  know what they are talking about. (emphasis added)

                What I have attempted to do in this paper up to this point is to question, frankly, what some scientists, in fact, are talking about - sincere though they may be.  Which scientists are correct, or at least have the best scientific theory to support the empirical facts?  I certainly do not consider myself an expert at all, but surely what I see are basic problems concerning scientific facts which are generally known and generally accepted as the best scientific explanation within the scientific community itself.  Scientific inaccuracies may be undesirable within the field of science itself.  Yet much of this scientific misinformation - if it is incorrect - has proliferated throughout the literature of philosophy, theology and biomedical ethics for many years.  This incorrect literature, in turn, has been institutionalized in philosophical, theological and biomedical journals, text books, encyclopedias, and computer programs on college campuses, "think tanks" and libraries nationally as well as internationally.  It has also been institutionalized in public policy development, the topic to which I will now very briefly turn.

III.  Public Policy Development

                Any number of "institutional" policy makers are influenced by the scientific and the bioethics literature - in most cases, legitimately so (Wikler, 1991;  Capron, 1989).  But many are also influenced by the above apparent inaccurate scientific/bioethics arguments, and inevitably incorporate these scientific inaccuracies and redefinitions into public policies.  I will only touch on but a very few examples here.

                The Harvard Medical School's (1968) definition of "brain death" - although probably a medically legitimate and useful concept - was based on neurological data similar to that discussed above, and is often the standard used by physicians to make a determination of the death of the patient before the withdrawal of treatment.  "Brain death" statutes have now become law in many states.

                Similar neurological data is also used to make a diagnosis of "permanent vegetative state" (PVS), a process which either has already been or, it is argued, should be adopted as a medical standard (Washington State, 1992;  Council on Scientific Affairs, etc., 1990;  Capron, 1992).  Yet PVS is still a questionable diagnosis (Steinbock, 1989;  Ross, 1992;  Tassaeau, 1991), which can lead to decisions to withdraw life-sustaining medical therapy.  Such decisions to withdraw therapy are often justified by the rationalistic philosophical claim that there is no longer a human "person" present (Robertson, 1991).

                Parallels of "brain death" with "brain birth" are made, leading to demands to forego medical treatment to defective neonates and newborns - since they also are not "persons". This is especially true for newborns with anencephaly (a diagnosis which is also difficult and questionable, designating a cluster of symptoms which differ significantly).  The parents of these infants receive many requests to donate the fresh living organs of their infants.  Walters (1992) argues for the medical standard of "proximate personhood" for making difficult treatment decisions involving imperiled newborns.  A developing individual's right to life, he claims, increases "as he or she approaches the threshhold of undisputed human personhood."  Anencephalics, because of their nature, may be treated "primarily (but not only) as a means" - especially when balanced against the good they may bring to others - i.e., as donors of organs (Walters, 1989) - a non-neutral and normative utilitarian theory of ethics.  And in a different context, reminescent of Descartes, many neonatal and pediatric surgeons have withheld pain relief from neonates and infants during and after surgery partly because of their belief that they cannot feel pain at those developmental stages.

                There are also charges growing that Roe v Wade was grounded in incorrect science (Carberry and Kmiec,1992).  Other legal commentators, e.g., Annas (1989-A; 1989-B), in defending Roe, follow the "symbolic personhood" arguments of Robertson (1988, 1989, 1991) - (which in turn relies heavily on the science of Grobstein).  Annas agrees with the Roe decision which held that "a State may not adopt one theory of when life begins to justify its regulation of abortion", and so opposes the Webster decision, which stated that "the life of each human being begins at conception."  But legitimate arguments can be made empirically that the life of each individual human being does begin at fertilization.  This is not a case of imposing one person's or group's "theories" on the rest of us - it is an objective, empirical fact.  Scientifically, even the "best fit" theory has to go with fertilization.  As Moore has put it:  "This cell [the zygote] results from fertilization of an oocyte, or ovum, by a sperm, or spermatozoon, and is the beginning of a human being" (Moore, 1982, p. 1; emphasis of the author).  Is science prepared to state that this is scientifically not true?

                The advent of in vitro fertilization has led to other policy arguments and policy decisions, on both the medical and the legal level.  The American Fertility Society has adopted the term "pre-embryo" in their professional quidelines.  Physicians have developed policies for the implantation, freeze-storage and experimental destruction of IVF human embryos - who, it is often argued, are not human beings or human "persons".  Legal precedent is set in the courts in cases involving surrogate motherhood (Annas, 1991), determination of decisions in the cases of the death of the "biological parents, and "ownership" of unwanted frozen embryos (Robertson, 1989).  Robertson (1986) argues in legal journals for new public policy determinations on IVF human embryos - quoting at length Grobstein's theory of human embryogenesis.  Robertson agrees with Grobstein that the "pre-embryo" is not a "person" yet, and thus possesses no moral or legal rights.  Robertson (1986) considers the pre-embryo as only property and having only "symbolic value" to the parents.  In the following quote from Robertson, arguing in the area of legal and public policy development, the reliance on the science of Grobstein, as well as the very rationalistic understanding of the philosophical term "potential" can be identified, and are quite confusing:

... consideration of embryo status is essential if we are to think clearly about and adopt appropriate policies concerning IVF and embryo manipulation... To assign a moral and legal status to the extracorporeal embryo, we must first examine the facts of early embryo development [which he then proceeds to quote from Grobstein].

                [The early human embryo is] clearly not a person in the usual sense that we use the term person...  [It] is similar to blood, bone marrow and other tissue or even solid organs, though there are important differences.

                ...Does the potential to become a person confer a particular moral and legal status on the embryo, a status that entails duties that limit what might be done with extracorporeal embryos?... I argue that the embryo does not have a moral status in and of itself.

                ...It is clear that there is no obligation to transfer embryos based on obligations to the persons who might then be born.  Future persons [i.e., IVF human embryos] have no claim on us unless our present choices will affect their well-being when they do come into being.  If they never come into being, they have not been harmed, since no person has ever existed to be harmed.  Thus there is no obligation to the person who might come into being as a result of transfer, because there is no such person.  No person exists to whom an obligation can be owed... Nor is there an obligation to the embryo in and of itself to be transferred, so that it might have the chance of realizing its potential personhood.  To say there is such a duty would be to assume that the nontransferred pre-embryo is a rights-bearing entity in and of itself.  It might become such an entity if certain favorable conditions and events occur.  But the potential to become a person does not mean that an entity should be treated as a person now, anymore than an acorn's potential to become an oak tree means that it now be regarded as an oak tree... Indeed such treatment would be very difficult in light of the biology of the embryo... It has no interests, and thus cannot be the subject of moral duties at this rudimentary stage [and thus can be used in experimental research]. (Robertson, 1986) (emphasis added)

                The use of IVF human embryos for research purposes, of course, is a major biomedical issue (Cefalo, 1991).  Medical researchers lobby Congress and federal regulatory committees to use "surplus" (Muggleton-Harris, 1991) or produced-for-research IVF human embryos in a great number of basic (destructive) research to perfect the IVF technique itself (see Aragona, 1991), improve embryonic cell biopsy, egg freezing techniques, superovulation and chrorionic biopsy techniques, embryonic sex selection and micro-injection techniques, as well as to screen viruses and bacteria.  IVF human embryos are also useful for research in fetal tissue transplants, selective breeding of human beings, genome analysis and germ line gene therapy, improvement of gene therapy techniques, nucleus substitition, implantation and gestation of the human embryo in the uterus of another animal and vice versa, production of new kinds of animals, creation of human embryos from the sperm of two different individuals or the ova of two different individuals, fusion of human embryos with other human embryos or animals to create chimeras, and parthenogenesis experiments.  They are also useful for drug testing, product testing, commercial purposes (e.g., hormones, blood proteins, anti-viral, anti-bacterial or anti-carcinogenic agents, vaccines, recombinant DNA experiments, and biological warfare experiments (Irving, 1991).  Can such large scale medical research be justified on the basis of the scientific and philosophical inaccuracies and problem as addressed above? 

                Many of these scientific, medical and legal conclusions and policies find their way to other  national and international policy levels.  For example, the use of human embryos and fetuses in purely experimental research is often justified on what at least the realist would consider the misperception of the non-personhood of the human embryo and the human fetus, and the legal reality of the Roe v Wade decision in the Supreme Court (NIH, 1988;  Annas, 1989, 1991;  Robertson, 1989, 1991).  International commissions pick up on national policy precedents.  Some Australian and French committees argue for "produced for research IVF embryos".  The Warnock Commission in England (1984) concluded that only after 14 days should the human embryo be afforded protection, because that is the limit of the period during which it is possible for the human embryo to implant in the uterine wall, after which the primitive streak is formed, and after which, they state, twinning does not occur.  Before 14 days the human embryo can be used for experimental research, since it is not a human being or a human person.  This conclusion was reached even though there was a common ground among the Warnock Committee members that at such time as it has become indisputably a living human being or person, "it would be morally unthinkable to carry out on the human organism, without consent, experiments of a damaging or mutilating kind" (Lockwood, 1988).  On the issue of PVS, the CCNE (French National Ethics Committee, 1986) affirmed that patients in a "permanent vegetative state" constitute "intermediaries between human beings and animals" - a view perhaps consonant with a Wallace-type scholastic philosophy - but one which is contested by Verspieren (Tassaeau, 1991) of the Centre Sevres, Paris, operating from a different philosophical definition of a human person.

DISCUSSION

Such are a few of the theoretical and practical influences which some of the seemingly basic scientific inaccuracies have had on other fields.  Perhaps what I have naively perceived as "incorrect" science is actually an erroneous judgment on my part.  If such is the case, I am certainly not alone, and the scientific community would well-serve those of us in other fields by clarifying for us which theories of human biochemistry, human genetics, human molecular biology and human embryological development "best fit" the scientific data.  The need for clarity is important, as complex decisions in other fields can go one way or another, depending on which scientific theory is perceived as the best explanation of the scientific facts.

                To parlay this into the "if...then" language of philosophy,  IF IT IS TRUE:  that the human zygote does not have all of the genetic information it needs to develop;  that it is not a human being;  that information from the mother determines the process of differentiation;  that it does not possess the information needed for developing past the blastocyst stage; that hydatidiform moles and teratomas proceed from normal human zygotes;  that all of the cells from the trophoblast layer are discarded after birth;  that no twinning takes place after 14 days;  that before that point there is no individual;  that all of the genetic input is complete only at the 2-cell stage;  that differentiation is completed by the 14-day stage;  that analogies between transient and stable natures, between the "nuclei" of radioisotopes, plants, animals and humans, between the generations of radioisotopes, plants, animals and humans, and between the causality of radioisotope "daughters" and human gametes can be validly and soundly made;  that chemists consider all atoms of an element to be identical and that they don't consider the individual atoms;  that parallels between brain death and brain birth, sentience and pain, consciousness or self-consciousness and "rational attributes", immature nerve nets and adult whole brain integration can be validly and soundly made ---------

THEN it is true that there is present no human organism, or human being, or human "person" at syngamy or before certain biological "marker events of personhood".  If that is true, then there is no entity bearing any moral or legal rights of its own.  If that is true, then early human embryos and fetuses may be used in a myriad of experimental research protocols, frozen and thawed with no personal or legal concern for damages, declared as property in the court rooms, aborted and harvested for organs or tissues.  To be both logically and "realistically" consistent, one would have to argue the same fate for normal healthy infants and young children (not to mention those of us who are not so "normal") - because both real "rational attributes" and real sentience and full brain organization are not complete until well after childhood.

                This same logic must hold at the other end of the life-spectrum.  The "souls" or "properties" of persons disappear one by one in the reverse order from whence they came:  first the "rational", then the "sensitive" - and finally we are left with a "something" which is senile or in a "permanent vegetative state".  If this "something" is now not a person, then it is probably ethical to experiment on it, medical treatment should be removed and/or ceased - and organ transplantation could begin.

                If this science and logic is true, then it should certainly be compiled into journal articles, text books, encyclopedias, encoded in professional medical standards, become hospital policy, be translated into state and federal statues, and be processed through Congressional hearings and court rooms.  Finally, it should be acted on "uniformly" by national commissions and regulatory agencies - and once so institutionalized, it should be considered as a "precedent" for other international bodies to adopt as well.

            IF IT IS NOT TRUE:  if the product of syngamy during human fertilization is a living, individual human being who must simultaneously be a human person;  if specifically human functions, proteins and enzymes are observed and produced from the zygote-stage on;  if specifically human tissue and organ systems are continuously produced from the zygote-stage on;  if all of the processes and stages of human embryogenesis are directly and completely encoded in the original human zygote (including the 2-cell and blastocyst stages, as well as totipotency, differentiation, nerve-net and whole brain formation - sometimes even twinning);  if methylation and the cascading effect are properly documented and understood;  if hydatidiform moles and teratomas do not proceed from normal human embryos;  if twinning does take place after 14 days;  if differentiation, the attainment of "rational attributes" or of sentience is not complete until at least early adulthood;  if there are profound differences between the "nuclei" of radioisotopes, plants animals and humans, between the generation of radioisotopes, plants, animals and humans, and between the causality of radioisotope "daughters" and human gametes;  if there are natural isotopes of most of the elements in the periodic table, and chemists are concerned with individual atoms;  if "models" of transient natures do not equal real human embryogenesis;  if there is no real scientifically demonstrated parallel between brain death and brain life, nerve nets and whole brains, consciousness, self-consciousness and sentience, and between immature and mature capacities --------

THEN it is true that there is no distinction between a human being and a human person which is empirically verifiable (or philosophically defensable).  If this is true, then a human zygote or a human fetus is a human being and a human person which is the bearer of his or her own moral and legal rights.  If that is true, then should they be used in purely experimental protocols, damaged by freezing and thawing, depicted as property in our court rooms, harvested for organs or tissues?  Infanticide, experimentation on the senile or on patients in a "permanent vegetative state", and the withholding and withdrawing of life-sustaining medical treatment (unless for the direct benefit of that person) would be morally unacceptable.  If this science is correct, then it would be reasonable for it to be compiled into journal articles, text books and encyclopedias, and different policies should be adopted in professional medical codes, hospital policies, state and federal statues;  processed before Congressional hearings and court rooms;  and institutionalized in national and international regulations.

CONCLUSION

So which scientific data and theories of nuclear chemistry, human biochemistry, human genetics, human molecular biology and human embryology best explain the empirical data?  Non-scientists cannot sort out the accuracy and reliability of these contradictory scientific claims.

                I have attempted in this paper to draw attention to the fact that scientific inaccuracies - even in considering only one current issue - have apparently "cascaded" throughout a number of other seemingly unrelated fields, influencing their theoretical superstructures and at least partially determining the development of public policy.  Aristotle's addage rings true - a small error in the beginning leads to a multitude of errors in the end.  Both kinds of scientific theories addressed here cannot both be correct and true.  Each one leads to a set of different conclusions when used by theorists in other fields.

                Perhaps most scientists have little time or interest to worry about such things.  Or perhaps he or she remains basically unaware of what happens to the data and theories once they have been submitted - other than for specifically scientific purposes.  I hope that this discussion may to some degree indicate how their data and theories can strongly influence other fields, and I would encourage scientists to consider, investigate, and discuss how they may help us sort it out.

NOTES

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3.  Aragona, John Matthew. (1991) Dangerous relations: doctors and extracorporeal embryos, the need for new limits to medical      inquiry. Journal of Contemporary Health Law and Policy 7:307-337.

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6.  Bennett, Michael V. (1989) Personhood from a neuroscientific perspective. in Doerr, et al. Abortion Rights and Fetal                "Personhood". Long Beach: Cresline Press.

7.  Bole, Thomas J. (1989) Metaphysical accounts of the zygote as a person and the veto power of facts. Journal of Medicine and      Philosophy 14:647-653.

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